A-7 Highway (Autovía del Mediterráneao) linking Murcia with Levante and Cataluña to the north, and Andalusia to the south.

A-7 / RM-2 Highway, linking Cartagena and Mar Menor with Valle del Guadalentín.

Other options are: RM-15 Highway, linking Valle del Guadalentín with the north-west of the province; RM-3 linking Bajo Guadalentín with Mazarrón coast and A-30 / A-7 linking Madrid and Albacete with the Region of Murcia and Valle del Guadalentín